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Derek Smith

World changing technology

Recensito in Canada 🇨🇦 il 9 maggio 2023

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Well researched and presented! Managed to stay away from all the ethical/moral debates and focused on the many positive aspects of the technology. Was hoping to learn a bit more about the Crispr technology but evidently that was not the intent of the author. Must be frustrating for the scientists to be constantly concerned about the patent/licensing nightmares. Too many parasites and undeserving copy-cats in the industry and the book dwells on this too much IMHO.

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kelsey thivierge-kinney

Enthralling Read

Recensito in Canada 🇨🇦 il 25 gennaio 2022

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I just finished a book called The Code Breaker by Walter Isaacson. It is essentially about the researchers who developed gene editing tools like CRISPR technology. I expected it to delve in CRISPR but instead it was a revealing look at the main personalities involved in CRISPR development with an emphasis on Jennifer Douda. This was unexpected for me but I found this book enthralling nevertheless. The author characterizes the community as a collection of prima donnas obsessed with being the first to be published in science/research journals and to win awards for recognition in their field of study. Although there was a collegiality among the researchers, there was a strong under current of back stabbing and pride. Of course the first to get published or who had the most accolades provided more access pork barrel research dollars too. The author sees this competition as a healthy rivalry that drives innovation. This environment of ego driven researchers has developed because they have no clinical experience. Front line doctors who actually do the hands on work are more concerned about producing results for their patients and have no problem openly consulting colleagues for the benefit of their patients and if a better solution is offered, they will adapt in the interests of their patients. It used to be that front line medicine was driven by front line care givers but now the medical system is all top down and the toxicity from communities like the researcher community has also filtered down as well and has contributed to the medical system that we have now that has lost it's way. The medical system has been completely captured by the medical industrial complex and by a community of "experts" who to even question labels you as a science denier. After all , who are we to question a Nobel prize winner. Nobel prize winning researchers like Doudna to present a false front of piousness but their egos have convinced them that their paradigm of medicine is correct because they think that their approach is purely and truly science driven. It is not and is easily provable when medical results are achieved outside of their system which they routinely ignore. If all you have is a hammer, everything is a nail. In the same way, if your perspective is big budget, complicated big science then all solutions are realm of the scientist priesthood class. This is childishly myopic. These people are lost in their paradigm and cannot see outside of it and do not consider solutions outside of their medical cartel. The only medical metric that counts is results and medical treatments outside of mainstream medicine are not to be ignored. Nobel prize winners with multiple letters after their names working in ivy league labs do not impress me anymore. Who am I to question experts which multiple letters after their name and awards like Nobel prizes? When it comes to solving health issues for me and my family, you answer to me that's who.

4 persone l'hanno trovato utile

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Geetha

Nice book

Recensito in India 🇮🇳 il 16 novembre 2022

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It's a biography....
Worth buying
Some topics are repeated/boring

Una persona l'ha trovato utile

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CEH

Good reading about groundbreaking science and scientists loosely packaged as an Isaacson biography

Recensito negli Stati Uniti 🇺🇸 il 18 marzo 2021

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This is an important book, but it is not a typical Isaacson biography. As the subtitle admits, it is a broader story about the science and scientists of gene editing and their impact on the human race. Like Isaacson's "pure" biographies, it is well-written and solidly-researched. Unlike those books, this one provides vignettes of many of the other scientists who collaborated with and competed against the principal subject, Jennifer Doudna. In doing so, it provides valuable insights into how scientific discoveries move from basic science to applied science. It also shows the international scale of those contributions and competitions. Photographs sprinkled across the book humanize the subjects and reinforce their diversity. The book also demonstrates how academic science is merging with startup companies today. Those aspects alone make this book valuable reading in our current age.

Isaacson does an admirable job of explaining the science to a broad range of readers, although there were times I would have appreciated some additional depth on the more important concepts. (There were also times when I felt he was providing too much detail on the peripheral players.)

A less well known author might not have classified this book as a biography. To benefit from Isaacson's well-deserved reputation for his biographies, the book properly emphasizes Jennifer Doudna, who shared the 2020 Nobel Prize in Chemistry with her former collaborator and competitor, Emmanuelle Charpentier. Doudna is fascinating subject and a wonderful role model for anyone interested in science, especially girls and women. Because of the book's broader sweep, we learn less about Doudna than we might have in a typical biography, which was a disappointment.

Although the breakthroughs the book describes will change the world, I was disappointed in Isaacson's treatment of two areas: First, while I appreciated his coverage of the moral and social justice questions surrounding human intervention in inheritable genetic traits, I found his personal views unnecessary and distracting. Second, I thought he shortchanged the additional invention needed to move gene editing forward. His cheerleading for Doudna and the other biotech scientists was appropriate and his demonstration of how easy gene hacking can be was a good warning for all of us. But much more will be required to make gene editing as safe and practical as it will need to be, particularly for edits that affect humanity's gene pools. Even a few more pages of foresight on those topics would have been appreciated.

Overall, this is an important book that deserves reading. It's also a clever effort by a brilliant biographer to market a broader story under the guise of a more traditional biography.

3 persone l'hanno trovato utile

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Anantha Narayan

Helps understand biogenetics but drags in parts

Recensito in India 🇮🇳 il 11 aprile 2021

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The Code Breaker traces the history of gene editing while simultaneously tracking Jennifer Doudna’s life — she has received a Nobel prize for being a pioneer of the CRISPR technology (an immune system that bacteria adapt whenever they get attacked by a new virus).

There is a key difference between this book and Isaacson’s biography of Steve Jobs. I did not learn anything new from the latter as I was aware of most of the key events in the life of Jobs and in the history of Apple; however the insights that he provided into Jobs’ personality and the behind-the-scenes happenings at Apple made it an extremely interesting read. The Code Breaker, on the other hand, was extremely informative given my limited knowledge of gene editing; however, in its quest for being informative, the book ends up being somewhat tedious.

Doudna has led an extremely laudable professional life. However, her personal life has been largely commonplace, and while Isaacson tries his hardest to create a sense of excitement around it, he fails to do so. He focuses all his efforts on this front in the third part of the book — Gene Editing — where he chronicles the intense rivalry between Feng Zhang and Doudna, tracing their race to get credit, important prizes and patents. But this attempt falls short.

The most interesting part of the book for me was the section where Isaacson explores the moral or ethical issues around gene-editing. This is best exemplified by the question, “would it be wrong to do so or would it be wrong not to do so”. Isaacson discusses where boundary lines should be drawn — somatic editing versus germline editing (the latter is hereditary), the use for treatment of diseases versus for enhancement of human characteristics, the types of diseases that should be edited out, disadvantages that are disabling versus those that are simply so because of societal constructs (such as homosexuality) and finally whether the individual or the community should control this. From this part onwards, the book is less about Doudna and more about the science.

The book ends on an optimistic note, while discussing the Covid-19 disease and the race to find a vaccine, on how reprogrammable RNA vaccines could pave a way for finding faster cures to diseases and pandemics in the future.

Pros: Helps understand the science of biogenetics, interesting debate on the ethical aspects

Cons: Drags in parts

56 persone l'hanno trovato utile

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Yo mama

Interesting info, very dry

Recensito negli Stati Uniti 🇺🇸 il 28 ottobre 2022

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The first 15% of this book was painful to get through. The meat of it was really exciting but the writing was still very dry. Most of my friends in my book club were not huge fans. I also felt like the author didn’t understand the science in a lot of places (I say that as someone who has two biology degrees and currently works in research) but I think he did a good job of explaining the work on a high level.

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Brian S.

Fine book about geneticists and genetics

Recensito negli Stati Uniti 🇺🇸 il 30 novembre 2022

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Walter Isaacson has given us a book that's well researched, well written, and extremely readable. I think the book would have been a bit better if there had been more details on science and fewer details on interpersonal issues.

However, The Code Breakers was enjoyable and informative. Fans of Walter Isaacson won't be disappointed.

2 persone l'hanno trovato utile

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Shashank Shet

Definitely an incredibly illuminating read

Recensito in India 🇮🇳 il 3 luglio 2022

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The author does a great job in portraying otherwise unknown facets of the research process, most notably the intricate strategies involved in pushing towards a publication. He also narrates her backstory in a very natural manner. Also each of the chapters that describes the science (with great abstraction) is perfectly relevant and builds towards the finale with great ease.

Una persona l'ha trovato utile

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Good Book Club book

Recensito in Canada 🇨🇦 il 13 gennaio 2023

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Our book club had a great discussion after reading this book. Only half of the group read it but after some pretty deep questions the other half vowed to read it! The book has some pertinent information on how the future of our everyday lives will or can look.

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Douglas Phillips, author of Quantum Space

I wanted to learn, and I did

Recensito negli Stati Uniti 🇺🇸 il 13 aprile 2021

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What is CRISPR and how does it relate to Covid-19 vaccines? And how is gene editing accomplished? I couldn't wait to learn! The Code Breaker is a fascinating story, well told. The author made it clear why Jennifer Doudna and Emmanuelle Charpentier deserved the 2020 Nobel prize. Yes, I was expecting a scientific biography - which this story is - but I was also hoping for 30% pure science so I could learn not just who/when/why, but HOW these superstars did what they did. Alas, the science was only about 10% of the story. Better than 0%, but I suspect the author knew more but chickened out explaining the details. Then there were the photos - about 60, all of scientists. Yes, they helped to visualize this grab bag of people, but the book could have included a few diagrams of the Cas9 gene or the CRISPR spacers within bacterial RNA, right? These concepts were key to the story, but their images were left to our imagination. Do some Google searches as you read - there are good materials out there. And, while I fully expected the Coronavirus portion to be near the end, I wish it had been longer with less space devoted to the competition in the early chapters. Thankfully, we got a good view into the amazing achievements of superb scientists who not only saved the day regarding coronavirus, but who ushered in a new era in human health for us all.

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